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Why those fat thighs may help you live longer
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People with fat in their thighs and backsides may live longer because the fat traps harmful fatty particles and actively secretes helpful compounds, according to a report published on Tuesday.

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Many studies have shown that people who accumulate fat around the abdomen and stomach are more likely to die of heart disease and other causes than bottom-heavy people, but the reasons are not clear.

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This may be because several different mechanisms are involved, said Konstantinos Manolopoulos of Britain's University of Oxford.

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"It is the protective role of lower body, that is, gluteofemoral fat, that is striking," Manolopoulos wrote in the International journal of Obesity.

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"The protective properties of the lower-body fat depot have been confirmed in many studies," he added.

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Fat on the bottom and thighs appears to store excess fatty acids, said Manolopoulos, who reviewed published scientific studies for his report.

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Pear-shaped people also appear to have lower levels of compounds called inflammatory cytokines -- signaling chemicals involved in the body's response to infection that also can play a role in heart disease and diabetes when they are inappropriately active.

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Fat on the legs may also absorb fats from the diet, keeping them from overwhelming the body when people overeat, Manolopoulos said.

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Cholesterol levels reflect a tricky balance between high density lipoprotein, the HDL or "good" cholesterol that removes harmful fats from the blood, and low-density lipoprotein, the "bad" LDL cholesterol that can harden and block the arteries.

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Fat in the thighs may also be more stable, he said, with studies showing abdominal fat breaks down quickly during fasting or stress, releasing potentially harmful components from the fat.

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"The exact regulatory mechanisms of fatty acid release and storage and their effect on short- and long-term fatty acid metabolism remain to be analyzed," Manolopoulos wrote.

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Leg fat may also be better at producing hormones such as leptin, which are made by fat and affect appetite and metabolism -- although Manolopoulos said this is poorly understood.

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Understanding all this could lead to better drugs for treating obesity and related disease such as diabetes and heart disease, Manolopoulos said.

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